Association between the 5-HTTLPR Polymorphism of the Serotonin Transporter Gene with the Efficiency and Tolerability of Selective Serotonin Reuptake Inhibitors

N. N. IvanetsEmail authorM. A. Kinkul’kinaYu. G. TikhonovaT. I. AvdeevaA. A. RagimovN. G. DashkovaO. E. KuznetsovA. V. MatveevT. A. IzyuminaS. V. Orlov

First Online: 05 May 2017

Objective. To identify the association between the 5-HTTLPR polymorphism of the serotonin transporter gene with the efficacy and tolerability of antidepressant therapy with a selective serotonin reuptake inhibitor (SSRI). Materials and methods. A complex clinical-psychopathological and genetic study of 38 patients with depression during SSRI treatment was conducted. Results and conclusions. Statistical associations between the 5-HTTLPR polymorphism and the levels of remission and tolerability were identified: carriers of the SS genotype rarely achieved remission and developed more severe side effects.

pharmacogenetics depression antidepressants 5-HTTLPR serotonin reuptake

Comments are closed.